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The incident happened at 2.20am on the Southbound carriage way near Leeming Bar and involved a Blue Ford Fiesta, a Grey Ford Puma and a black Land Rover Defender.
Sadly, the passenger in the Land Rover, a woman in her early seventies, was pronounced dead at the scene.
The driver of the Land Rover, also in his early seventies, was taken to hospital with serious but not believed to be life- threatening, injuries.
A 22-year-old man from Malton has been arrested on suspicion of Causing Death by Dangerous Driving, Drink Driving and Drug Driving. He remains in custody at this time.
Please quote reference number 12210223751 when passing on any information.